Interdisziplinäres Zentrum für Klinische Forschung (IZKF)

Wild-type KRAS is a novel therapeutic target for melanoma contributing to primary and acquired resistance to BRAF inhibition (2017) Dietrich P, Kuphal S, Spruss T, Hellerbrand C, Boßerhoff AK Journal article Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice (2017) Regensburger M, Schreglmann SR, Stoll S, Rockenstein E, Loskarn S, Xiang W, Masliah E, Winner B Journal article Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1 (2017) Pasutto F, Zenkel M, Hoja U, Berner D, Uebe S, Ferrazzi F, Schödel J, et al. Journal article Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia (2017) Allison R, Edgar JR, Pearson G, Rizo T, Newton T, Guenther S, Berner F, et al. Journal article Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci (2017) Aung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, Thorleifsson G, Mizoguchi T, Igo RP, et al. Journal article Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway (2017) Leitherer S, Clos J, Liebler-Tenorio EM, Schleicher U, Bogdan C, Soulat D Journal article ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis (2017) Mahli A, Saugspier M, Koch A, Sommer J, Dietrich P, Lee S, Thasler R, et al. Journal article JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment (2017) Zhang Y, Liang R, Chen CW, Mallano T, Dees C, Distler A, Reich A, et al. Journal article Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies (2017) Müller F, Stookey S, Cunningham T, Pastan I Journal article Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages (2017) Maier C, Bergmann C, Weinkam R, Kittan N, Schett G, Distler J, Beyer C, Ramming A Journal article