Lehrstuhl für Pharmazeutische Chemie

A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands, New Drug Leads and PROTACs (2022) Huber M, Toy L, Schmidt M, Vogt H, Budzinski J, Wiefhoff MFJ, Merten N, et al. Journal article A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro (2022) Aillaud I, Kaniyappan S, Chandupatla RR, Ramirez LM, Alkhashrom S, Eichler J, Horn A, et al. Journal article Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs (2022) El Hamdaoui Y, Zheng F, Fritz N, Ye L, Tran MA, Schwickert K, Schirmeister T, et al. Journal article Structure-Based Evolution of G Protein-Biased μ-Opioid Receptor Agonists (2022) Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hübner H, et al. Journal article Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer (2021) Budzinski J, Maschauer S, Kobayashi H, Couvineau P, Vogt H, Gmeiner P, Roggenhofer A, et al. Journal article A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure (2021) Kriegel M, Wiederanders HJ, Alkhashrom S, Eichler J, Muller Y Journal article Functionally selective activation of the dopamine receptor D2 is mirrored by the protein expression profiles (2021) Wenk D, Ignatchenko V, Macklin A, Hübner H, Gmeiner P, Weikert D, Pischetsrieder M, Kislinger T Journal article N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide y Y4Receptor Ligands Results in Picomolar Binding Constants (2021) Konieczny A, Conrad M, Ertl FJ, Gleixner J, Gattor AO, Grätz L, Schmidt MF, et al. Journal article, Original article A pair of non‐competing neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model (2021) Peter AS, Roth E, Schulz S, Fraedrich K, Steinmetz T, Damm D, Hauke M, et al. Journal article, Original article Cleavage of Organosolv Lignin to Phenols Using Nitrogen Monoxide and Hydrazine (2021) Hofmann L, Altmann LM, Fischer O, Prusko L, Xiao G, Westwood NJ, Heinrich M Journal article