PD Dr. Heiko Bruns

Department of Medicine 5 – Haematology and Oncology

Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity (2019) Haug T, Aigner M, Peuser MM, Strobl C, Hildner K, Mougiakakos D, Bruns H, et al. Journal article Innate extracellular vesicles from melanoma patients suppress beta-catenin in tumor cells by miRNA-34a (2019) Lee JH, Dindorf J, Eberhardt M, Lai X, Ostalecki C, Koliha N, Gross S, et al. Journal article, Original article Loss of TP53 modifies the quantity and protein load of extracellular vesicles in leukemic B-cells and influences functional crosstalk within the tumor microenvironment (2019) Izquierdo-Alvarez E, Vorholt D, Wiederstein J, Lobastova L, Blakemore SJ, Krueger M, Hansen H, et al. Conference contribution Bone marrow stroma cells promote a S100A8/A9high subset of chemoresistant AML blasts with distinct metabolic features in a Jak/STAT-dependent manner (2019) Böttcher M, Panagiotidis K, Mentz K, Bruns H, Mackensen A, Mougiakakos D, Völkl S Conference contribution AML-derived exosomes promote induction of myeloid-derived suppressor cells in an mTOR-signaling-dependent fashion (2019) Jitschin R, Tohumeken S, Saul D, Bruns H, Braun M, Mackensen A, Mougiakakos D Conference contribution Human monocytes display different levels of CD137/4-1BB expression linked to certain immunometabolic features (2019) Stoll A, Bruns H, Saul D, Mackensen A, Mougiakakos D Conference contribution Combination of lenalidomide and vitamin D enhances MOR202-mediated cytotoxicity of macrophages: It takes three to tango (2019) Flamann C, Busch L, Mackensen A, Bruns H Journal article Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation (2019) Jitschin R, Böttcher M, Saul D, Lukassen S, Bruns H, Loschinski R, Ekici AB, et al. Journal article A novel immunoregulatory function of beta-2-microglobulin as a promoter of myeloid derived suppressor cell induction (2019) Bruns H, Jitschin S, Gamali S, Saul D, Böttcher M, Mackensen A, Jitschin R, Mougiakakos D Journal article DNA Damage-Response Pathway in Lymphoma Determines Interactions with Macrophages By Altered PD-Li Expression and Fxosome Formation (2018) Vorholt D, Izquierdo-Alvarez E, Sackey B, Schmitz J, Nickel N, Blakemore S, Knittel G, et al. Conference contribution