A084: The pathogenetic role of tissue-resident memory T cells in acute Graft-versus-Host-disease
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.05.2020
End date : 30.11.2022
Extension date: 31.05.2023
Project details
Scientific Abstract
T cell mediated intestinal inflammation in acute Graft-versus-Host-Disease (GI-GvHD) represents a life-threatening and therapeutically challenging complication in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Interestingly, the role of tissue-resident memory T cells (Trm) in this context is unknown. Here, we plan studies to assess the development, migration, location and functionality of Trm cells in GI-GvHD both in murine experimental models and in men.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Professur für Mukosale Immuntherapie
Medizinische Fakultät
