P040 (Biochemie, Mol. Medizin): FoxO-dependent autophagic flux in mitochondrial homeostasis and adult neural stem/progenitor cell function
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.09.2019
End date : 31.08.2020
Project details
Scientific Abstract
Mitochondrial function is crucial for maintenance of the adult neural stem/progenitor cell (NSPC) pool. I found that loss of FoxO transcription factors leads to hyperproliferation and depletion of NSPCs and impairs autophagy-lysosome pathway activity. Moreover, loss of FoxOs is associated with mitochondrial dysfunction. I propose to investigate mitochondria as targets of FoxO-dependent autophago-lysosomal degradation, to establish a FoxO-mitophagy axis in the control of adult NSPC function.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institut für Biochemie
Medizinische Fakultät
