E029 (Biochemie u. Mol. Medizin: The impact of lysosome dysfunction on stem cell ageing
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.07.2020
End date : 15.01.2023
Extension date: 15.07.2023
Project details
Scientific Abstract
Recent data indicates that adult neural stem cell dysfunction and the resulting impairment of adult hippocampal neurogenesis contributes to cognitive deficits in human ageing and neurodegenerative diseases. The mechanisms underlying ageing-associated neural stem cell dysfunction are largely unknown. This project will investigate the hypothesis that dysfunction of lysosome-dependent degradation pathways is a major contributor for hippocampal neural stem cell dysfunction during ageing.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Professur für Molekulare Medizin mit dem Schwerpunkt Molekulare Bildgebung
Medizinische Fakultät
