E028: The Cranial Neural Crest Regulatory Network And Molecular Causes of Orofacial Clefts
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.07.2020
End date : 15.01.2023
Extension date: 15.07.2023
Project details
Scientific Abstract
Orofacial clefts are frequent congenital malformations. Etiology is complex, poorly understood and involves environmental and genetic factors. We could identify several cranial neural crest transcription factors and chromatin remodelers as key regulators of palatal development. We now use genome-edited cell lines and mouse mutants to determine the exact function and relationship of these factors in their regulatory network and thus better understand palatal development and orofacial clefting.
Involved:
Contributing FAU Organisations:
Lehrstuhl für Biochemie und Pathobiochemie
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Zahn-, Mund- und Kieferheilkunde, insbesondere Kieferorthopädie
Medizinische Fakultät
