P065: The homeoprotein transcription factor Engrailed-1 mediates fibroblast activation and skin fibrosis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 29.06.2020
End date : 30.04.2021
Extension date: 28.06.2021
Project details
Scientific Abstract
Systemic sclerosis (SSc) is a prototypic fibrotic disease, with TGF-beta as a key mediator of fibroblast activation. Engrailed-1 (EN1) identifies a fibroblast lineage with intrinsic fibrogenic potential. We showed that EN1 was upregulated in fibrotic skin by TGF-beta, and that EN1 knockout partially prevented fibroblast activation and fibrosis. Next, we aim to study EN2 in fibrosis, to evaluate how EN1 is upregulated and to provide further evidence for the role of EN1 in fibroblast activation.
Involved:
Contributing FAU Organisations:
Department of Medicine 3 – Rheumatology and Immunology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
