IZKF-J70 (M4): From gene to function: a translational pipeline for gene discovery and allele testing in kidney disease
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.10.2018
End date : 30.09.2021
Project details
Scientific Abstract
The genetic background of chronic kidney disease in adults in poorly investigated. This study aims to identify novel candidate genes by Whole Exome Sequencing in adult patients with chronic kidney disease. Transcriptome analysis of patient specific primary cells will be employed to functionally characterize these candidate genes. CRISPR/Cas9 based zebrafish experiments will transfer the in vitro findings in an animal disease model.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 4 – Nephrology and Hypertension
Medizinische Fakultät
