D035: Linking a renal cancer associated SNP in the chromatin remodeller DPF3 with hypoxia signalling
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2020
End date : 31.12.2022
Project details
Scientific Abstract
The renal cancer risk SNP on chromosome 14q24.2 creates a novel Hypoxia inducible transcription factor (HIF)-binding DNA element in an intronic region of the DPF3 gene, a member of the SWI/SNF chromatin remodelling complex. DPF3 is upregulated in a SNP- and HIF-dependent fashion in renal tubular cells. We investigate the regulation of DPF3 in renal cells and cancer as well as its contribution to global chromatin status and transcription factor binding to critical DNA regions.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 4 – Nephrology and Hypertension
Medizinische Fakultät
