A081: Host cell receptor and neuropathogenicity of mammalian 1 orthobornavirus
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2020
End date : 30.06.2022
Extension date: 15.12.2022
Project details
Scientific Abstract
Recently, we detected Borna disease virus (BoDV-1) as the cause of human fatal encephalitis. Previous studies have addressed the immune response and viral replication, but the host cell receptor of BoDV-1 remained unknown. We will use an unique BoDV-1 patient isolate to search for this receptor, and we will address the possible direct, non-immune related neuropathogenic potential of BoDV-1, as well as antiviral (chemo)therapeutic options, in IPSC derived human neuronal 3D organoid cultures.
Involved:
Contributing FAU Organisations:
Lehrstuhl für Klinische und Molekulare Virologie
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
