A083: The role of SAMHD1 in CMV/ HIV coinfections
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2020
End date : 30.06.2022
Extension date: 31.12.2022
Project details
Scientific Abstract
HIV patients coinfected with CMV show increased morbidity and mortality, even on therapy. Despite high coinfection rates, surprisingly little is known about molecular interactions of CMV and HIV. We found that CMV blocks the HIV restriction factor SAMHD1 to facilitate its own replication. This finding finally provides a handle to explain how CMV enhances HIV replication in the host. Thus, we will address the working hypothesis that CMV infection boosts HIV replication by inactivating the SAMHD1.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Clinical and Molecular Virology
Medizinische Fakultät
