P048: Role of Collagen IV during retrovirus transmission
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.05.2019
End date : 15.03.2020
Project details
Scientific Abstract
The oncogenic retrovirus Human T-cell leukemia virus type 1 transmits via cell-cell contacts and viral biofilms seem to constitute a major route of virus transmission. In viral biofilms, extracellular concentrated viral particles are embedded in cocoon-like structures containing collagens (COL) of unknown composition. Here, we hypothesize that the viral transactivator Tax-1 selectively induces expression of COL4 and that COL4 is important for biofilm formation and HTLV-1 transmission.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Clinical and Molecular Virology
Medizinische Fakultät
