IZKF-J74 (PS): The role of CtBP1 in hippocampal and cortical neuroplasticity
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2019
End date : 30.06.2021
Extension date: 31.07.2021
Project details
Scientific Abstract
The pathways leading to physiological and maladaptive neuroplasticity are overlapping and strictly controlled by transcriptional regulators such as CtBP1. Following neuronal activity, CtBP1 translocates from nuclei and enables transcription of a number of genes that are involved in memory formation and also seizure generation. Using CtBP1 knock-out mice model, we aim to identify candidate pathways regulating hyperexcitability and develop new intervention mechanisms against these alterations.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Psychiatry and Psychotherapy
Medizinische Fakultät
