J094: Decoding the effect of inflammatory bowel disease on microglia activation and synucleinopathy
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.12.2021
End date : 31.05.2024
Extension date: 30.11.2024
Project details
Scientific Abstract
Inflammatory bowel disease (IBD) predisposes for synucleinopathies like Parkinson Disease. This is putatively caused by propagation of chronic inflammation into the brain. The hypothesis of this project is that chronic inflammation in IBD activates microglia in distinct brain regions, thereby mediating neuronal pathology and aggravating synucleinopathy. This hypothesis will be tested in post mortem brain tissue of IBD patients and mice with colitis.
Involved:
Contributing FAU Organisations:
Department of Neurology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
