J079: Functional impact of PD-L1:PD-1-interactions on diet-induced obesity and dysbiosis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.09.2019
End date : 28.02.2022
Extension date: 31.08.2022
Project details
Scientific Abstract
Obesity has become one of the leading global health concerns. Current research suggests a link between obesity, PD-L1 and the microbiome. This project will investigate the role of the microbiome on the function the regulation of adipose tissue T cell responses mediated by innate expression of PD-L1 in mice and humans. Using state-of-the-art RNA and 16S rRNA sequencing, flow cytometry and co-culture systems, we will reveal important mechanisms for the control of adipose tissue inflammation.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene
Medizinische Fakultät
