P085: Generation of Duotoxins for the treatment of cancer
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2021
End date : 30.06.2022
Project details
Scientific Abstract
We found immunotoxins - fusion proteins of toxins and antibodies - synergistically enhanced 100-fold by Paclitaxel. We developed Duotoxins combining Paclitaxel-like DM1 and immunotoxins on one antibody. But, conventional immunotoxins cannot be conjugated efficiently. After switching to full-length antibodies, an active Duotoxin was generated. Here, we aim to use novel technology to extend the concept to other targets before applying for an extension of current DFG grant.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 5 – Haematology and Oncology
