J085: Analysis of cell-type-specific roles and crosstalk of IL36R signaling in gut inflammation and fibrosis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.11.2020
End date : 15.11.2021
Extension date: 15.11.2023
Project details
Scientific Abstract
Intestinal fibrosis is a common complication in IBD and has limited therapeutic options. IL36R ligands are upregulated in CD and UC patients as well as CD patients with stenosis. The systemic blockade of IL36R signaling reduces intestinal inflammation and fibrosis in vivo. Deciphering the cell-type-specific roles of IL36 via the newly generated IL36Rfl/f mouse strain will help to understand the mode of action of a neutralizing IL36R antibody in humans.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Medizinische Fakultät
