A078: Smurf2-dependent repression of type I IFN signalling in inflammatory bowel disease and mucosal healing
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2021
End date : 30.06.2023
Extension date: 31.12.2023
Project details
Scientific Abstract
To understand the role played by ubiquitination of type I interferon in the pathogenesis of inflammatory bowel disease we intend to induce DSS colitis in two newly generated conditional mouse strains i.e. Stat2 and Smurf2 in experimental colitis models. CRISPR/Cas, three dimensional organoids coupled with Nanostring and RNA-Seq/GO analysis will be used to understand molecular mechanisms underlying DSS findings. Data will be validated using samples from IBD patients and controls.
Involved:
Contributing FAU Organisations:
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Innere Medizin I (Medizin 1)
Medizinische Fakultät
