P083: Rho GTPases within intestinal epithelium and type2 immunity for the differentiation of secretory IECs
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.10.2021
End date : 30.09.2022
Project details
Scientific Abstract
Basic research focusing on TCs differentiation might contribute to the understanding of pleiotropic immune functions of the intestinal epithelium, which can be exploited in the context of immunomodulation. Our preliminary data support an interplay between type2 cytokines and Rac1/RhoA function within IECs playing a role in the differentiation of IECs towards a TCs fate. Our aim is then to decipher the molecular mechanisms operating behind intrinsic/extrinsic control of TCs cell fate decision.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Medizinische Fakultät
