ZKF-J68 (M1): Role of the transcription factor GATA4 in intestinal wound healing, inflammation, and cancer
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.10.2017
End date : 31.03.2020
Project details
Scientific Abstract
GATA4 is expressed in the intestinal epithelia and regulates metabolic functions in physiological states. We have shown that a microbiota-derived signal regulates epithelial GATA4. Epigenetic silencing of GATA4 frequently occurs in colon cancer patients. However, its role in bridging gut barrier, inflammation and carcinogenesis remains poorly defined. We seek to identify pathways and strategies to restore GATA4 in cancer to provide new therapeutic alternatives in the treatment of colon cancer.
Involved:
Contributing FAU Organisations:
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Human Genetics
Medizinische Fakultät
