J093: Lipid mechanisms of drug instrumentalization: the role of serotonergic system
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2022
End date : 30.06.2024
Extension date: 31.12.2024
Project details
Scientific Abstract
Alcoholism and depression are highly comorbid disorders. Neutral sphingomyelinase (NSM) is suggested as a missing link between emotional status and alcohol consumption due to the downstream effects on the serotoninergic system. A new line of mice with NSM gene knockout specifically in the brain serotoninergic system was created to investigate if the interaction between NSM and the brain serotoninergic system determines the comorbidity between negative emotional state and alcohol consumption.
Involved:
Liubov Kalinichenko
Project Leader
Arif Bülent Ekici
Project Member
Christian Alzheimer
Project Member
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Physiologie
Department of Psychiatry and Psychotherapy
Institute of Human Genetics
Medizinische Fakultät
