J090: Regulatory functions of eosinophils during pathological bone remodelling
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2022
End date : 30.06.2024
Project details
Scientific Abstract
A healthy skeleton relies on a balance between bone-forming osteoblasts and bone-resorbing osteoclasts. A shift towards increased osteoclast activity can therefore lead to bone loss. The immune system strongly affects osteoclast biology, usually promoting osteoclast development. Interestingly, we demonstrated that eosinophils negatively regulate osteoclast formation and activity. Thus, it is of high relevance to unveil the molecular mechanisms underlying this regulatory function of eosinophils.
Involved:
Darja Andreev
Project Leader
Philipp Tripal
Project Member
Zoltan Winter
Project Member
Georg Schett
Project Member
Arif Bülent Ekici
Project Member
Arnd Kleyer
Project Member
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Department of Anaesthesiology
Institute of Human Genetics
Lehrstuhl für Innere Medizin III
FAU Optical Imaging Competence Center (FAU OICE)
Medizinische Fakultät
