P096: Orphan nuclear receptor DAX-1 mediates fibroblast activation and skin fibrosis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2022
End date : 31.08.2022
Project details
Scientific Abstract
SSc is the systemic rheumatic disease with the highest disease-related mortality. We identified DAX-1 as a mediator of fibroblast activation. We showed that DAX-1 is upregulated in fibrotic skin and that knockdown of Dax-1 ameliorates skin fibrosis. We plan to further characterize the mechanism of DAX-1 upregulation and study its potential transcriptional role in fibroblast activation as well as its potential antifibrotic role in 3D skin models and precision cut tissue slices from SSc skin.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
