J100: A TRM-inducing mucosal vaccination against lung-metastasizing cancer
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2023
End date : 30.06.2025
Extension date: 31.12.2025
Project details
Scientific Abstract
The presence of tumor-resident memory T cells (TRM) positively correlates with prognosis in many cancers. In our preliminary data, lung TRM induced by a mucosal vaccine efficiently protected against lung metastasis in a preclinical breast cancer model. We want to investigate the vaccine efficacy against lung metastases at different disease stages and the contribution of TRM and their unique features to this efficacy. The efficacy will also be assessed in combination with radio- and chemotherapy.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Clinical and Molecular Virology
Department of Radiation Oncology
Medizinische Fakultät
