P126: Mesenteries as a novel ex vivo co-culture model to study peritoneal metastasis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.05.2023
End date : 30.04.2024
Extension date: 01.09.2024
Project details
Scientific Abstract
Although peritoneal metastasis correlates with poor survival in colorectal cancer (CRC), knowledge on its molecular mechanisms is rather limited. Thus, there is a crucial need for developing novel in vitro models that recapitulate peritoneal seeding and identify putative markers for therapeutic approaches. Our study aims to implement a new ex vivo mesentery model for co-culture with CRC spheroids and organoids to study gene-specific effects on tumor cell adhesion and invasion in the peritoneum.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Pathology
Medizinische Fakultät
