A104: Mechanical regulation of intestinal T cell egress in inflammatory bowel disease
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.01.2023
End date : 15.07.2025
Extension date: 30.11.2025
Project details
Scientific Abstract
It is still unclear, how the in vivo trafficking of autoreactive T cells in IBD is coordinated. Preliminary data indicate that mechanical properties regulate the motility of gut T cells. Thus, we aim to investigate the interplay of intestinal T cell mechanics and trafficking in a joint effort combining the expertise of two clinician scientist PIs in cell trafficking and bioimaging. We ultimately hope to identify new targets for organ-selective IBD therapy controlling T cell dynamics in the gut.
Involved:
Sebastian Zundler
Project Leader
Stefan Uderhardt
Project Leader
Jochen Guck
Project Member
Ben Fabry
Project Member
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Lehrstuhl für Biophysik
Lehrstuhl für Biologische Optomechanik
Professur für Immunzellmigration TT (Else Kröner Clinician Scientist-Professur)
Medizinische Fakultät
