E037: CtBP1 in oligodendroglial development and myelination
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2023
End date : 31.07.2025
Extension date: 30.11.2025
Project details
Scientific Abstract
Mutations in transcriptional corepressor CtBP1 cause the neurodevelopmental disorder HADDTS. Functional CtBP1 studies in the central nervous system so far focused on neurons. We recently found that CtBP1 is also important in oligodendrocytes. Here we will characterize the oligodendroglial functions of CtBP1 and the underlying cellular and molecular mechanisms in mice and a human ES cell-derived cellular disease model to show that defects in oligodendrogenesis and myelination contribute to HADDTS
Involved:
Anna Fejtová
Project Leader
Michael Wegner
Project Leader
Julio Vera González
Project Member
Marisa Karow-Falk
Project Member
Beate Winner
Project Member
Melanie Küspert
Project Member
Contributing FAU Organisations:
Professur für Tumorimmunologie (Schwerpunkt Systembiologie)
Professur für Molekulare Psychiatrie
Professur für Stammzell-Modelle seltener neuraler Erkrankungen
Professur für Biochemie und Molekulare Neurowissenschaften
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Biochemie und Pathobiochemie
Medizinische Fakultät
