M5-IZFK-D043: Mechanisms controlling functionality and persistence of CD19.CAR T-cells

FAU own research funding: EFI / IZKF / EAM ...


Start date : 16.03.2023

End date : 15.09.2025

Extension date: 15.03.2026

Project details

Scientific Abstract

CD19-directed chimeric antigen receptor (CAR) T-cells have shown high efficacy in the treatment of B-cell malignancies and are now emerging as a standard approach for patients with relapsed and refractory disease. Despite this progress, a significant portion of patients still experience resistance to treatment. We aim to understand the intrinsic mechanisms controlling persistence and effector functions of CAR T-cells and therefore identify strategies to overcome treatment failure.

Involved:

Julio Vera González Project Leader Simon Völkl Project Leader Arif Bülent Ekici Project Member

Contributing FAU Organisations:

Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Professur für Tumorimmunologie (Schwerpunkt Systembiologie) Institute of Human Genetics Department of Medicine 5 – Haematology and Oncology Medizinische Fakultät

Research Areas

Microscope SVG Advanced Projects Field of Research