A093: Epithelial ACLY as a key immunometabolic regulator of intestinal inflammation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2023
End date : 31.12.2025
Extension date: 30.06.2026
Project details
Scientific Abstract
We have identified the enzyme ATP Citrate Lyase (ACLY) as a key immunometabolic regulator of intestinal inflammation. We therefore hypothesize that diminished ACLY expression in the intestinal epithelium drives the pathogenesis of Inflammatory Bowel Disease. To evaluate our hypothesis, we plan to elucidate the regulation of Acly, its molecular mode of action and its functional impact for the steady-state gut and for intestinal inflammation using newly generated knockout mice.
Involved:
Christoph Becker
Project Leader
Stefan Wirtz
Project Member
Imke Atreya
Project Member
Rocío Lopez Posadas
Project Member
Claudia Günther
Project Member
Raja Atreya
Project Member
Gerhard Krönke
Project Member
Contributing FAU Organisations:
Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Professur für Molekulare Gastroenterologie
Professur für Gastrointestinale Pathophysiologie
Medizinische Fakultät
