A095: The 2-O-methylation of viral RNA regulates innate immune sensing by MDA5

FAU own research funding: EFI / IZKF / EAM ...

Start date : 01.01.2023

End date : 30.06.2025

Extension date: 31.12.2025

Overview

Publications

(1)

Project details

Scientific Abstract

2-O-Methylation of mRNA by cellular methyltransferases (MTases) enables discrimination of self and non-self. We found that SARS-CoV-2 lacking the viral MTase Nsp16 triggers an enhanced innate immune response that depends on the RNA receptor MDA5. Thus, we will analyse Nsp16 as a means of SARS-CoV-2 to counteract innate immune sensing and will test the hypothesis that the 2-O-methylation of viral RNA in general protects from sensing by the pattern recognition receptor MDA5.

Involved:

Thomas Gramberg Project Leader

Contributing FAU Organisations:

Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Institute of Clinical and Molecular Virology Medizinische Fakultät

Research Areas