P128-OA: FICD-mediated AMPylation: a potential modulator of Parkinsons disease?
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.09.2023
End date : 31.08.2024
Project details
Scientific Abstract
Protein AMPylation, which can be catalyzed by FICD, has emerged as a modulator of neurogenesis. The role of FICD-mediated AMPylation in neurodegeneration, however, has been less understood. Our preliminary data suggest a promoting function of FICD in the aggregation of alpha synuclein (aSyn), which is linked to the pathogenesis of Parkinsons diseases. This project aims to investigate the pathological relevance of FICD-mediated AMPylation in aSyn aggregation-associated neurodegeneration.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Molecular Neurology
Medizinische Fakultät
