J105: Glucose transporter type 1: Metabolic controller of plasma cell longevity and antibody function?

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.10.2023

End date : 31.03.2026

Project details

Scientific Abstract

The secretion of correctly glycosylated protective antibodies by long-lived plasma cells is essential for our immune protection. To survive and produce antibodies, long-lived plasma cells require an optimized metabolism. The aim of this study is to determine whether the glucose transporter GLUT1 plays a role in the metabolism of long-lived plasma cells and the functionality of their antibodies. Therefore, we will study a GLUT1-deficient mouse model and patients with GLUT1-deficiency syndrome.

Involved:

Katharina Pracht Project Leader Anja Lux Project Member Regina Trollmann Project Member

Contributing FAU Organisations:

Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Professur für Kinder- u. Jugendmedizin Schwerpunkt Neuropädiatrie Department of Molecular Immunology Professur für Integrated Immunology Medizinische Fakultät

Research Areas

Microscope SVG Junior Projects Field of Research