P140-OA: iPSC-derived neural crest cells to study unique roles of chromatin remodeling complexes in palate development
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.10.2023
End date : 15.06.2024
Project details
Scientific Abstract
Orofacial clefts are the second-most congenital malformation. Palate development depends on cranial neural crest cells (CNCCs). CNCCs undergo diverse differentiation programs accompanied by vast changes in gene expression, to which the chromatin remodeling complexes BAF and EP400/TIP60 contribute. We will analyze the function of both complexes in iPSC-derived CNCCs in proliferation and in differentiation to tissues relevant for palatogenesis by CRISPR/Cas9-guided knockout of each central ATPase.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Orthodontics and Orofacial Orthopaedics
Medizinische Fakultät
