J104: Impact of Stat5 in CD4+ T cells on chronic colitis

FAU own research funding: EFI / IZKF / EAM ...


Start date : 01.11.2023

End date : 30.04.2026

Project details

Scientific Abstract

T cells play a key role in IBD, but the impact of Stat5 in CD4+ T cells for chronic colitis is unclear so far. Based on preliminary data demonstrating spontaneous chronic colitis in conditional Stat5 KO mice and decreased Stat5 expression in IBD, I hypothesize that Stat5 in CD4+ T cells counteracts colitis. Thus, in this project, I will explore the mechanisms and effects of CD4-specific Stat5 signalling for experimental colitis and IBD, aiming to identify novel approaches for future therapy.

Involved:

Tanja Müller Project Leader Stefan Uderhardt Project Member Claudia Günther Project Member

Contributing FAU Organisations:

Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Department of Medicine 3 – Rheumatology and Immunology Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Medizinische Fakultät

Research Areas

Microscope SVG Junior Projects Field of Research