IZKF-P060: ERVs in the anti-tumoral immune response via IFN-signaling during development of MIBC
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.06.2020
End date : 31.05.2021
Project details
Scientific Abstract
To investigate if high amounts of tumor cell dsRNA derived from ERVs regulate the tumor immune microenvironment by activating the viral alarm or IFN response leading to high anti-tumor lymphocyte infiltration including establishment of tertiary lymphoid structures as well as adaptive responses (immune checkpoints, negative regulatory immune cells and ECM production) already in early precursor stages of muscle-invasive bladder cancer and how they might evade the immunosurveillance.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Pathology
Medizinische Fakultät
