J107: Deciphering the PU.1 transcriptional network in osteoblasts and its role in osteoproliferative arthritis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2024
End date : 31.08.2026
Project details
Scientific Abstract
PU.1 controls the transcriptional network of matrix production in fibrotic fibroblasts. We have now found that PU.1 is also expressed in matrix-producing osteoblasts. In this proposal, we aim to study the PU.1 network in biopsies from patients with osteoproliferative arthritis by imaging mass cytometry, to dissect PU.1-driven transcription in human osteoblastogenic cultures by ATTAC/CHIP/RNA-seq, and to use a novel osteoblast-targeting PU.1 inhibitor in experimental osteoproliferative arthritis.
Involved:
Simon Rauber
Project Leader
Olaf Prante
Project Member
Arif Bülent Ekici
Project Member
Tobias Bäuerle
Project Member
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Professur für Molekulare Bildgebung und Radiochemie
Institute of Human Genetics
Professur für Multimodale Bildgebung in der präklinischen Forschung
Medizinische Fakultät
