J108: Characterisation of the CFTR complex and effects of a CFTR-modulating triple therapy in immune cells
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2024
End date : 30.06.2026
Project details
Scientific Abstract
This project aims at identifying the expression of the CFTR complex and functionally characterising its role in in peripheral blood mononuclear cells in the context of Cystic Fibrosis (CF). Moreover, the effects of a CFTR-modulating therapy with Elexacaftor - Tezacaftor - Ivacaftor (ETI) on immune cell function and regulation will be examined in a CFTR knock-out cell line and a CF pig model as well as primary patient-derived cells.
Involved:
Alexander Schnell
Project Leader
Ben Fabry
Project Member
Claudia Günther
Project Member
Iris Stolzer
Project Member
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Biophysik
Department of Paediatrics and Adolescent Medicine
Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology
Medizinische Fakultät
