P148: Differential modulation of Wnt/beta-catenin signaling in kidney disease
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.03.2024
End date : 31.12.2024
Project details
Scientific Abstract
We identified a new configuration of the Wnt signaling mechanism at the luminal membrane of the kidney tubule. Thus, tubular cell culture and zebrafish models are used to further investigate how Wnt ligands activate b-catenin in the tubule, and in particular how this affects the intercalated cells of the collecting duct, a cell type important for acid-base regulation. The findings resulting from these efforts could help to identify tubular targets in the therapy of nephrotic syndrome.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 4 – Nephrology and Hypertension
Medizinische Fakultät
