P110: Analysis of the molecular function of MAGOH in melanoma cells and its impact on cell viability
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.03.2024
End date : 31.12.2024
Project details
Scientific Abstract
MAGOH is part of the exon junction complex that binds to mRNA and regulates alternative splicing or mRNA degradation via "nonsense mediated decay". This project investigates the role of MAGOH in malignant melanoma. Preliminary data showed that a loss of MAGOH leads to cell death in melanoma cells, which will be further investigated in different melanoma cell lines, as well as healthy cells. Furthermore, the molecular mechanisms leading to the reduced viability will be analyzed.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Lehrstuhl für Biochemie und Molekulare Medizin
Medizinische Fakultät
