P144: Microbiota-derived histamine induces resolution of peripheral inflammation via the central nervous system
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.02.2024
End date : 31.01.2025
Project details
Scientific Abstract
Propionate is produced by the gut microbiota and has anti-inflammatory properties. Our preliminary data shows that bacterial histamine production is increased upon propionate treatment. Histamine is able to induce rapid resolution of peripheral inflammation in arthritic mice via the activation of H3 receptor, which is mainly expressed on cells of the central nervous system (CNS). In this project we aim to unravel the role of the CNS in mediating histamine-induced resolution of inflammation.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
