P099: Influence of the translocated microbiome on the TCR repertoire
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.04.2022
End date : 15.01.2024
Project details
Scientific Abstract
Changes in (T cell receptor) TCR repertoire can directly impact on the breath and magnitude of antigen-specific T cell responses. During treated HIV infection, dysfunctional T cell responses associate with inflammation that is at least in part driven by microbial translocation. Therefore, we aim to investigate the relationship between the translocated microbiome, the TCR repertoire and T cell functionality, with emphasis on vaccine-induced antigen-specific responses.
Involved:
Contributing FAU Organisations:
Institute of Clinical and Molecular Virology
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Medizinische Fakultät
