J091: Glucocorticoid-induced immune-metabolic reprogramming of macrophages
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2022
End date : 30.06.2024
Project details
Scientific Abstract
Glucocorticoids are amongst the most important anti-inflammatory drugs, promoting inflammatory resolution via the functional reprogramming of macrophages, a process that promotes itaconate production. Though itaconate is a metabolite participating in immune-metabolic rewiring, its role and effects, as with the underlying mechanisms involved in its production, on immunometabolism and inflammatory resolution remain unknown, yet could contribute to further optimizing glucocorticoid treatment.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
