P105: Characterization of CD83 as a pro-resolving checkpoint molecule for human macrophages
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2022
End date : 30.06.2023
Project details
Scientific Abstract
Regulatory macrophages are crucial to induce resolution of inflammation. Excessive macrophage activation is associated with transplant rejection or chronic of inflammatory diseases. Our preliminary murine data revealed that sCD83 induces regulatory macrophages , whilst mCD83 deletion drives macrophages towards a pro-inflammatory phenotype. This project aims to translate these interesting findings into the human macrophages system.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Immune Modulation
Medizinische Fakultät
