P045: Modulation of the IL-6 signaling pathway in Herpes Simplex Virus Type-1-infected mature dendritic cells
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.06.2019
End date : 15.06.2020
Project details
Scientific Abstract
The focus of the present project is the investigation of Herpes simplex virus type-1 (HSV-1)-mediated modulations of the IL-6 signaling pathway in mature dendritic cells (mDCs). In particular, the underlying molecular mechanisms of reduced IL-6R?, gp130 and STAT3 expression will be analyzed on directly-infected versus uninfected bystander mDCs. Moreover, we will elucidate whether non-infectious L-particles, released from HSV-1-infected cells, are essential/sufficient to induce these modulations.
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Immune Modulation
Medizinische Fakultät
