P155-OA: Intestinal epithelial barrier disruption as the trigger to Prevotella-induced arthritis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2024
End date : 30.06.2025
Project details
Scientific Abstract
In previous our research, higher Prevotella levels were found in rheumatoid arthritis patients´ gut. We aim to define mechanisms increasing arthritis incidence by Prevotella intestinalis in murine model. We hypothesize that outer membrane vesicles of P. intestinalis disrupt the epithelial barrier, leading to a reduction of IL-18 levels. This disruption allows dendritic cells, primed by the P. intestinalis, to play a pivotal role in triggering Th17 cell-mediated arthritis in mice.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Medicine 3 – Rheumatology and Immunology
Medizinische Fakultät
