P147: Modelling the intestinal barrier to analyse HTLV-1 transmission
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.11.2024
End date : 31.10.2025
Project details
Scientific Abstract
The focus of the present project is the effect of the human T cell leukemia virus (HTLV-1) on dendritic cells (DCs) in two models. The project focuses on the transmission of HTLV-1 to DCs across an intestinal barrier, analyzing the phenotype of DCs and the mechanism of transmission. For this purpose, two models, a 2D transwell and a 3D organs-on-a-chip model will be established. Finally, both models will be compared regarding their advantages, disadvantages and differences in the DC phenotype.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Clinical and Molecular Virology
