P165-OA: Lipid nanoparticles for targeted delivery of HIV-1 antigens and genetic immunomodulators
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2025
End date : 31.12.2025
Project details
Scientific Abstract
This project aims to develop lipid nanoparticle (LNP) vaccines for targeted delivery of HIV-1 antigens and checkpoint inhibitors (CPI) mRNA. By displaying HIV-1 antigens on the LNP surface, we seek to efficiently target and activate Env-specific B cells. Concurrent delivery of CPI mRNA into the cells is anticipated to induce local checkpoint inhibitor production, modulating immune response without systemic CPI exposure.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Clinical and Molecular Virology
