P162-OA: Investigating biological links between chronic stress and epigenetic dysregulation
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2025
End date : 31.12.2025
Project details
Scientific Abstract
Chronic stress has long-lasting effects on the hippocampal function, but it still remains unclear how. We investigate stress-induced epigenetic changes as a biological link between chronic stress and brain dysfunction. Our preliminary data has identified lamin B1 as a target of chronic stress. Lamin B1 is an epigenetic factor that maintains heterochromatin. We will investigate how chronic stress downregulates lamin B1, and how stress-induced reduction of lamin B1 affects epigenetic regulation.
