P172: Decoding the Impact of Human Cytomegalovirus Glycoprotein B Variants on Viral Fusion
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.03.2025
End date : 28.02.2026
Project details
Scientific Abstract
HCMV glycoprotein B variants are being studied with respect to viral fusion and syncytium formation. The specific objectives are: (1) identification of polymorphisms that enhance or inhibit fusion; (2) characterization of the fusion phenotype of these viruses in different cell lines; and (3) development of a murine CMV with hyperfusogenic gB. This study aims to understand the regulation of gB fusion activity and to identify potential diagnostic markers for HCMV pathogenicity.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Clinical and Molecular Virology
